Two different reels of fishing line were purchased for each of the two brands, and sections of line were cut from each reel. Taylor in 1996 in order to compare the strengths of two brands of fishing line exposed to two different levels of stress. The fishing line experiment was run by C. Since the effect of the drug ( A) was of primary importance, and since the effects of B and C were of interest only in the form of an interaction with A, the main effects of B and C and the \(\) combinations on the whole plots is also a randomized block design. Each day was then subdivided into 4 whole plots of size 8, where the eight measurements within a whole plot were taken fairly close together in time. Each treatment combination was measured once per day. The blocks were of size 32, each set of 32 observations being measured on a single day. Consequently, the experiment was divided into blocks, whole plots and split plots. In many pharmacological studies, time of day has an effect on the response due to changing laboratory conditions, etc. The response was the amount of fluid (in milliliters) measured in the pleural cavity of an animal after having been administered a particular treatment combination. The experimental units used in the study were \(n=64\) rats. A second factor was the dose of the drug (factor B at \(b=2\) levels), and the third factor was the length of time (factor C at \(c=2\) levels) that a measurement was taken after injection by a substance known to cause an inflammatory reaction. The experiment concerned the evaluation of eight drugs (factor A at \(a=8\) levels) for the treatment of arthritis. Wooding in the Journal of Quality Technology in 1973. An experiment designed as a split-plot design was described by W.M.
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